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Schematic of a typical mouse electrocardiogram (ECG) showing the various parameters measured in this study. Signals through atria are shown in fuchsia and ventricular signals are in black and blue.

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Schematic of a typical mouse electrocardiogram (ECG) showing the various parameters measured in this study. Signals through atria are shown in fuchsia and ventricular signals are in black and blue.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques:

Representative ECG at 12 weeks from male uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC (blue). Similar changes were observed in female mice. Black arrow shows a prolonged T wave. Black dots represent baseline.

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Representative ECG at 12 weeks from male uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC (blue). Similar changes were observed in female mice. Black arrow shows a prolonged T wave. Black dots represent baseline.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques: Infection

Changes in atrial electrical activity of the ECG in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC. Panels ( A , B ) show P wave amplitude and duration. Panel ( C ) shows corrected PRc interval and Panel ( D ) shows PR segment. Data shown are mean ± SEM, with n = 8 mice per group (four males and four females). The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. Black arrows indicate the start of DTG/TDF/FTC treatment. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Changes in atrial electrical activity of the ECG in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC. Panels ( A , B ) show P wave amplitude and duration. Panel ( C ) shows corrected PRc interval and Panel ( D ) shows PR segment. Data shown are mean ± SEM, with n = 8 mice per group (four males and four females). The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. Black arrows indicate the start of DTG/TDF/FTC treatment. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques: Activity Assay, Infection, Software, Control

Changes in ventricular depolarization/repolarization activity of the ECG in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC. Panel ( A ) shows QRS complex, Panel ( B ) shows the S wave amplitude, Panel ( C ) shows J wave amplitude and Panel ( D ) shows QTc interval. Data shown are mean ± SEM, with n = 8 mice per group, four males and four females. Black arrows indicate the start of DTG/TDF/FTC treatment. The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Changes in ventricular depolarization/repolarization activity of the ECG in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC. Panel ( A ) shows QRS complex, Panel ( B ) shows the S wave amplitude, Panel ( C ) shows J wave amplitude and Panel ( D ) shows QTc interval. Data shown are mean ± SEM, with n = 8 mice per group, four males and four females. Black arrows indicate the start of DTG/TDF/FTC treatment. The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques: Activity Assay, Infection, Software, Control

Changes in ventricular repolarization/electrical silent region of the ECG (latter) in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC (blue). Panel ( A ) shows STc interval, Panel ( B ) shows the ST-Tc segment, Panel ( C ) shows TPc interval and Panel ( D ) shows TQc interval. Data shown are mean ± SEM, with n = 8 mice per group, four males, and four females. Black arrows indicate the start of DTG/TDF/FTC treatment. The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Changes in ventricular repolarization/electrical silent region of the ECG (latter) in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC (blue). Panel ( A ) shows STc interval, Panel ( B ) shows the ST-Tc segment, Panel ( C ) shows TPc interval and Panel ( D ) shows TQc interval. Data shown are mean ± SEM, with n = 8 mice per group, four males, and four females. Black arrows indicate the start of DTG/TDF/FTC treatment. The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques: Infection, Software, Control